# = Joint first author * = Corresponding author
Book Chapters
T. Wharton, S. Krajcovicova, D. R. Spring
Cysteine Re-bridging Using Divinyl Pyrimidine Reagents for the Generation of Antibody–Drug Conjugates
Methods in Molecular Biology: Bioconjugation Methods. Springer Nature, 2026 (Editor: Deiters, Alexander) here
T. Wharton, S. Krajcovicova, D. R. Spring
Generating DAR 2 Antibody–Drug Conjugates Using Bis-Divinyl Pyrimidine Reagents
Methods in Molecular Biology: Antibody–Drug Conjugates. Springer Nature, 2027. (In revision)
Research Articles
24. Selective Inhibition of CK2: Emerging Strategies and Future Directions
A. R. Sokhal, S. Krajcovicova, J. Iegre, P. Brear, C. De Fusco, P. A. Glossop, D. Cawkill, M. Hyvonen, D. R. Spring
J. Med. Chem. 2026, 69, 17584–17601.
23. Peptide Marriages: Modular Assembly of Multi-Agonist Therapeutics
K. A. Kostadinova, J. L. Venne, S. Krajcovicova*, J. Dodgson, W. F. J. Hogendorf, T. E. D. Nielsen, D. Hymel, H. Bolt, A. Collinson, J. Revell, D. R. Spring
Chem. Eur. J. 2026, 32, e71280.
22. Multicomponent Stapling of Glucagon-like Peptide-1 Enables Receptor-Guided PROTAC Delivery
J. L. Venne, S. Krajcovicova*, G. Davies, H. Bolt, J. Revell, D. R. Spring
Angew. Chem. Int. Ed. 2026, 65, e9595531.
Frontispiece cover page
21. On-Resin Assembly of Cysteine-Reactive Linkers for Site-Selective Antibody Bioconjugation
S. Krajcovicova, T. Wharton, D. R. Spring
Nat. Protoc. 2026, 21, s41596-026-01376-4.
20. Towards the Targeted Protein Degradation of CK2: Design and Synthesis of CAM4066-Based PROTACs
S. Day-Riley, S. Krajcovicova, A. R. Sokhal, J. L. Venne, P. Brear, M. Hyvonen, B. C. Whitehurst, J. S. Carroll, D. R. Spring
Beilstein J. Org. Chem. 2026, 22, 611–619.
19. A Platform for SpyCatcher Conjugation to Native Antibodies
S. Krajcovicova, T. Wharton, C. Driscoll, T. A. King, M. Howarth, D. R. Spring
Chem. Sci. 2025, 16, 10602–10609.
18. Ideas Behind the Tryptophan-Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling
S. Krajcovicova*
ChemMedChem 2024, 19, e202400148.
17. Site-Selective Peptide Functionalisation Mediated via Vinyl-Triazine Linchpins
J. Sydenham, H. Seki, S. Krajcovicova, T. Schober, L. Zeng, T. Deingruber, D. R. Spring
Chem. Commun. 2024, 60, 706–709.
16. A Cell-Active Cyclic Peptide Targeting the Nrf2/Keap1 Protein–Protein Interaction
J. Iegre#, S. Krajcovicova#, A. Gunnarsson, L. Wissler, H. Käck, A. Luchniak, S. Tångefjord, F. Narjes, D. R. Spring
Chem. Sci. 2023, 14, 10800–10805.
15. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation
S. Krajcovicova*, D. R. Spring
Angew. Chem. Int. Ed. 2023, e202307782. VIP Paper.
14. Disulfide Re-Bridging Reagents for Single-Payload Antibody–Drug Conjugates
T. A. King, S. J. Walsh, M. Kapun, T. Wharton, S. Krajcovicova, M. S. Glossop, D. R. Spring
Chem. Commun. 2023, 59, 9868–9871.
13. Modulation of FLT3-ITD and CDK9 in Acute Myeloid Leukaemia Cells by Novel Proteolysis-Targeting Chimeras (PROTAC)
E. Reznickova#, S. Krajcovicova#, M. Perina, M. Kovalova, M. Soural, V. Krystof
Eur. J. Med. Chem. 2022, 243, 114792.
12. [68Ga]Ga-DFO-c(RGDyK): Synthesis and Evaluation of Its Potential for Tumour Imaging in Mice
S. Krajcovicova, A. Daniskova, K. Bendova, Z. Novy, M. Soural, M. Petrik
Int. J. Mol. Sci. 2021, 22, 7391.
11. Polymer-Supported Synthesis of N-Substituted Anthranilates as Building Blocks for N-Arylated 3-Hydroxyquinolin-4(1H)-ones
S. Krajcovicova, K. Vychodilova, J. Hlavac
RSC Advances 2021, 11, 9362–9365.
10. 1,4,6-Trisubstituted Imidazo[4,5-c]pyridines as Inhibitors of Bruton’s Tyrosine Kinase
S. Krajcovicova, R. Jorda, D. Vanda, M. Soural, V. Krystof
Eur. J. Med. Chem. 2021, 211, 113094.
9. Scaffold Hopping of the SYK Inhibitor Entospletinib Leads to Broader Targeting of the BCR Signalosome
R. Jorda#, S. Krajcovicova#, P. Kralova, M. Soural, V. Krystof
Eur. J. Med. Chem. 2020, 204, 112636.
8. Solid-Phase Synthesis for Thalidomide-Based Proteolysis-Targeting Chimeras (PROTAC)
S. Krajcovicova, R. Jorda, D. Hendrychova, V. Krystof, M. Soural
Chem. Commun. 2019, 55, 929–932.
7. Configuration-Dependent Medium-Sized Ring Formation: Chiral Molecular Framework with Three-Dimensional Architecture
N. Cankarova, A. La-Venia, S. Krajcovicova, V. Krchnak
J. Org. Chem. 2019, 84, 636–644.
6. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and Their Use in Imaging of Cellular Drug Uptake and Distribution
S. Krajcovicova, J. Stankova, P. Dzubak, M. Hajduch, M. Soural, M. Urban
Chem. Eur. J. 2018, 24, 4957–4966.
5. Triterpenic Azines: A New Class of Compounds with Selective Cytotoxicity to Leukemia Cells CCRF-CEM
J. Pokorny, S. Krajcovicova, M. Hajduch, M. Holoubek, S. Gurska, P. Dzubak, T. Volna, I. Popa, M. Urban
Future Med. Chem. 2018, 10, 483–491.
4. A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors
S. Krajcovicova, T. Gucky, D. Hendrychova, V. Krystof, M. Soural
J. Org. Chem. 2017, 82, 13530–13541.
3. Diastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides
L. Maier, P. K. Khirsarya, O. Hylse, S. K. Adla, L. Cernova, M. Poljak, S. Krajcovicova, E. Weis, S. Drapela, K. Soucek, K. Paruch
J. Org. Chem. 2017, 82, 3382–3402.
2. Mitsunobu C-Alkylation of β-Alkoxycarbonyl 2-Nitrobenzenesulfones and Its Use for the Rapid Synthesis of Novel Benzothiazine Derivatives
M. Drabikova#, S. Krajcovicova#, M. Soural
Tetrahedron 2017, 73, 6296–6306.
1. Solid-Phase Synthetic Strategies for the Preparation of Purine Derivatives
S. Krajcovicova, M. Soural
ACS Comb. Sci. 2016, 18, 371–386.
